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BactoAI: Research predictions from assembled genomes.

BactoAI model statistics

BactoAI model statistics

  • 97.1%
    sensitivity / 96.4% specificity
    Meropenem, internal hold-out, n=125
  • Under 10 minutes
    Under 10 minutes from an assembled genome
    Sequencing and assembly come first
  • 3
    3 antibiotics currently modeled, with more planned
    Meropenem · Ciprofloxacin · Cefotaxime
The Stakes

A silent pandemic is outpacing the drugs we have to fight it.

1.27M+
Estimated deaths attributable to bacterial AMR in 2019

Source: The Lancet, 2022, global bacterial AMR burden estimate for 2019.

16-20h
Further incubation for phenotypic testing after isolation
10M
Estimated annual AMR deaths by 2050 under the 2015 no-action scenario

Source: Review on Antimicrobial Resistance, 2015. Older modeled projection, not a measured outcome.

$100T
Estimated cumulative global economic cost by 2050 under the 2015 no-action scenario

Source: Review on Antimicrobial Resistance, 2015. Older modeled projection, not a measured outcome.

Bacterial culture plate used for phenotypic susceptibility testing
Today
16-20h
A further 16-20 hours of incubation for phenotypic testing after isolation
→
With BactoAI
<10
Under 10 minutes from an assembled genome. Sequencing and assembly come first. Supports phenotypic testing; does not replace it.
"Antimicrobial resistance is one of the top ten global public health threats facing humanity."
World Health Organization
Research and entrepreneurship journey
Grant
CDIE Catalyst
Program
East Africa Biodesign
First project pitch
GEES Bootcamp
The Problem

Antimicrobial resistance is one of the greatest global health threats.

Traditional culture-based diagnostics delay clinical decisions, contributing to inappropriate antibiotic use, prolonged hospital stays, and increasing antimicrobial resistance.

1.27M+

Estimated deaths attributable to bacterial AMR in 2019. Source: The Lancet, 2022 (doi:10.1016/S0140-6736(21)02724-0).

16-20 hrs

A further 16-20 hours of incubation for phenotypic testing after isolation. BactoAI: Under 10 minutes from an assembled genome. Sequencing and assembly come first.

Research

BactoAI is a research prototype, not approved for clinical use. It supports phenotypic susceptibility testing and does not replace it.

Our Solution

Meet BactoAI

BactoAI is a research prototype for antimicrobial resistance prediction. Under 10 minutes from an assembled genome; sequencing and assembly come first. It is most useful for isolates already sequenced, for example in surveillance.

STEP 1
Patient

Clinical presentation & bacterial infection identified.

STEP 2
Sample

Bacterial isolate collected from the patient.

STEP 3
Sequencing and assembly

Sequencing and assembly → assembled genome (FASTA).

STEP 4
BactoAI

ML models analyze genomic features.

STEP 5
Prediction

Resistance profile & confidence per antibiotic.

STEP 6
Decision support

Research prototype; supports, not replaces, phenotypic susceptibility testing.

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